Author: Monika Abedin Sigg; Tabea Menchen; Jeffery Johnson; Chanjae Lee; Semil P. Choksi; Galo Garcia; Henriette Busengdal; Gerard Dougherty; Petra Pennekamp; Claudius Werner; Fabian Rentzsch; Nevan Krogan; John B. Wallingford; Heymut Omran; Jeremy F. Reiter
Title: Evolutionary proteomics uncovers ciliary signaling components Document date: 2017_6_22
ID: 9y8r277c_40
Snippet: The left-right axis defect in Enkur morphant Xenopus led us to investigate if the 415 requirement for ENKUR in left-right patterning was conserved in mammals. We examined the 416 developmental expression of mouse Enkur by situ hybridization, which revealed that, similar to 417 X. laevis, 2-4 somite stage mouse embryos express Enkur exclusively in the node ( Figure 6E and 418 S5F). Immunofluorescent staining indicated that, again like X. laevis, E.....
Document: The left-right axis defect in Enkur morphant Xenopus led us to investigate if the 415 requirement for ENKUR in left-right patterning was conserved in mammals. We examined the 416 developmental expression of mouse Enkur by situ hybridization, which revealed that, similar to 417 X. laevis, 2-4 somite stage mouse embryos express Enkur exclusively in the node ( Figure 6E and 418 S5F). Immunofluorescent staining indicated that, again like X. laevis, ENKUR localizes to nodal 419 cilia, suggesting that mouse ENKUR may function in mouse left-right patterning ( Figure 6F ). 420 All rights reserved. No reuse allowed without permission.
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