Selected article for: "antigen detection and IgG antibody"
Author: Emily R Adams; Rekha Anand; Monique I Andersson; Kathryn Auckland; J Kenneth Baillie; Eleanor Barnes; John Bell; Tamsin Berry; Sagida Bibi; Miles Carroll; Senthil Chinnakannan; Elizabeth Clutterbuck; Richard J Cornall; Derrick W Crook; Thushan De Silva; Wanwisa Dejnirattisai; Kate E Dingle; Christina Dold; David W Eyre; Helen Farmer; Sarah J Hoosdally; Alistair Hunter; Katie Jeffrey; Paul Klenerman; Julian Knight; Clarice Knowles; Andrew J Kwok; Ullrich Leuschner; Chang Liu; Cesar Lopez-Camacho; Philippa C Matthews; Hannah McGivern; Alexander J Mentzer; Jonathan Milton; Juthathip Mongkolsapaya; Shona C Moore; Marta S Oliveira; Fiona Pereira; Timothy Peto; Rutger J Ploeg; Andrew Pollard; Tessa Prince; David J Roberts; Justine K Rudkin; Gavin R Screaton; Malcolm G Semple; Donal T Skelly; Elliot Nathan Smith; Julie Staves; David Stuart; Piyada Supasa; Tomas Surik; Pat Tsang; Lance Turtle; A Sarah Walker; Beibei Wang; Charlotte Washington; Nicholas Watkins; James Whitehouse; Sally Beer; Robert Levin; Alexis Espinosa; Dominique Georgiou; Jose Carlos Martinez Garrido; Hannah Thraves; Elena Perez Lopez; Maria del Rocio Fernandez Mendoza; Alberto Jose Sobrino Diaz; Veronica Sanchez
Title: Evaluation of antibody testing for SARS-Cov-2 using ELISA and lateral flow immunoassays
  • Document date: 2020_4_20
    • ID: 5trox1i5_36
    Snippet: The copyright holder for this preprint . https://doi.org/10.1101/2020.04. 15.20066407 doi: medRxiv preprint demonstrating that SARS-CoV anti-spike IgG contributes to a proinflammatory response associated with lung injury in macaques. 19 Our data on the kinetics of antibody responses to SARS-CoV-2 infection build upon studies of hospitalised patients in China reporting a median 11 days to seroconversion for total antibody, with IgM and IgG serocon.....
    Document: The copyright holder for this preprint . https://doi.org/10.1101/2020.04. 15.20066407 doi: medRxiv preprint demonstrating that SARS-CoV anti-spike IgG contributes to a proinflammatory response associated with lung injury in macaques. 19 Our data on the kinetics of antibody responses to SARS-CoV-2 infection build upon studies of hospitalised patients in China reporting a median 11 days to seroconversion for total antibody, with IgM and IgG seroconversion at days 12 and 14 respectively; 15 another similar study reports 100% IgG positivity by 19 days. 16 Our ELISA data show IgG titres rose over the first 3 weeks of infection and that IgM testing identified no additional cases. Methods to enhance sensitivity, especially shortly after symptom onset, could consider different sample types (e.g. saliva), different antibody classes (e.g. IgA) 20 , T-cell assays or antigen detection. 21 In contrast to others, 16,22-24 we did not find evidence of an association between disease severity and antibody titres. We observed several LFIA false positives, which may have potentially resulted from cross-reactivity of non-specific antibodies (e.g. reflecting past exposure to other seasonal coronavirus infections).

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