Author: Matthew C. Wong; Sara J. Javornik Cregeen; Nadim J. Ajami; Joseph F. Petrosino
Title: Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019 Document date: 2020_2_13
ID: dnxhtbxn_19
Snippet: The main limitations of this analysis are the lack of additional viral datasets arising from pangolins or the availability of coronavirus genomes isolated from pangolins that could be used Close up of the S1 domain with surrounding regions. Grey boxes highlight the S1-NTD subdomain and the S1-CTD or RBD subdomain. In the RBD subdomain the homology of the Pangolin-CoV genome exceeds that of RaTG13-CoV as compared to the nCoV-2019 strain. Panel C: .....
Document: The main limitations of this analysis are the lack of additional viral datasets arising from pangolins or the availability of coronavirus genomes isolated from pangolins that could be used Close up of the S1 domain with surrounding regions. Grey boxes highlight the S1-NTD subdomain and the S1-CTD or RBD subdomain. In the RBD subdomain the homology of the Pangolin-CoV genome exceeds that of RaTG13-CoV as compared to the nCoV-2019 strain. Panel C: Multiple alignment of the receptor biding motif at the amino acid level. Boxes highlight the key amino acid residues involved in ACE2 receptor binding. The nCoV-2019 and Pangolin-CoV strains are identical at all five amino acid residues, whereas RaTG13-CoV strain differs at four out of five compared to nCoV-2019. Labels: nCoV-2019 -outbreak strain; Pangolin-CoV -pangolin coronavirus identified in this study; RaTG13-CoV -R. affinis coronavirus; Bat-CoV -bat coronavirus (MG772933.1) author/funder. All rights reserved. No reuse allowed without permission.
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