Author: Matthew C. Wong; Sara J. Javornik Cregeen; Nadim J. Ajami; Joseph F. Petrosino
Title: Evidence of recombination in coronaviruses implicating pangolin origins of nCoV-2019 Document date: 2020_2_13
ID: dnxhtbxn_1
Snippet: An outbreak of respiratory illness caused by a novel coronavirus (nCoV-2019) 1 , first identified in Wuhan China, has resulted in over twenty thousand confirmed cases worldwide (WHO Situation Report, February 5 2020). Data available to date has led to the hypothesis that the outbreak strain originated from bats. The nCoV-2019 has been reported to share 96% sequence identity to the RaTG13 genome, a coronavirus isolated from an intermediate horsesh.....
Document: An outbreak of respiratory illness caused by a novel coronavirus (nCoV-2019) 1 , first identified in Wuhan China, has resulted in over twenty thousand confirmed cases worldwide (WHO Situation Report, February 5 2020). Data available to date has led to the hypothesis that the outbreak strain originated from bats. The nCoV-2019 has been reported to share 96% sequence identity to the RaTG13 genome, a coronavirus isolated from an intermediate horseshoe bat (Rhinolophus affinis) 2 . RaTG13 is the most closely related coronavirus genome to nCoV-2019, however other viral strains may have contributed to its genomic content. To explore this hypothesis, we examined several viral metagenomic datasets for potential coronaviruses that could harbor RBMs closer to nCoV-2019. We report evidence of a coronavirus recovered from a Malayan pangolin (Manis javanica) viral metagenomic dataset 3 that shares a higher sequence identity at a crucial segment of the genome involved in host infection ( Figure 1 ). This result indicates a potential recombination event and a more complex origin for the nCoV-2019 strain.
Search related documents:
Co phrase search for related documents- high sequence identity and host infection: 1, 2
- high sequence identity and Malayan pangolin: 1
- high sequence identity and novel coronavirus: 1, 2, 3, 4
- high sequence identity and outbreak strain: 1
- high sequence identity and recombination event: 1, 2
- high sequence identity and sequence identity: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76
Co phrase search for related documents, hyperlinks ordered by date