Evolved sequence features within the intrinsically disordered tail influence FtsZ assembly and bacterial cell division

Megan C. Cohan; Ammon E. Posey; Steven J. Grigsby; Anuradha Mittal; Alex S. Holehouse; Paul J. Buske; Petra A. Levin; Rohit V. Pappu

Progresses in advancing our understanding of sequence-to-conformation relationships of IDRs / IDPs (Mollica et al., 2016; Schneider et al., 2015) have opened the door to using sequence design as a tool to investigate the functional and phenotypic effects of modulating sequence-to-conformation relationships of IDPs / IDRs (Das et al., 2016; Sherry et al., 2017; Staller et al., 2018) . These studies have been directed at yeast proteins that control cell cycle arrest (Das et al., 2016) , mating type switching (Martin et al., 2016) , and transcriptional activation (Staller et al., 2018) and mammalian systems that regulate cell differentiation (Sherry et al., 2017) , tumor suppression (Borcherds et al., 2014) , and transcriptional regulation (Portz et al., 2017) . There is also growing interest in the roles of IDRs / IDPs as modulators of the driving forces for the formation of membraneless organelles and protein-RNA bodies in eukaryotic systems (Dao et al., 2018; Harmon et al., 2017; Hernandez-Vega et al., 2017; Lin et al., 2017; Lin et al., 2018; Mitrea et al., 2018; Mitrea and Kriwacki, 2016; Wei et al., 2017) .