Author: Megan C. Cohan; Ammon E. Posey; Steven J. Grigsby; Anuradha Mittal; Alex S. Holehouse; Paul J. Buske; Petra A. Levin; Rohit V. Pappu
Title: Evolved sequence features within the intrinsically disordered tail influence FtsZ assembly and bacterial cell division Document date: 2018_4_14
ID: 2rzfuy33_61
Snippet: In order to understand the functional roles played by the CTL, we resorted to an approach driven by sequence design that is guided by physical principles underlying the sequence-to-conformation relationships of IDRs . A similar approach was pursued to uncover the roles of functional polyampholytic IDRs in p27, an inhibitor of cyclindependent kinases in yeast (Das et al., 2016) , and the IDR within the RAM region of the Notch intracellular domain .....
Document: In order to understand the functional roles played by the CTL, we resorted to an approach driven by sequence design that is guided by physical principles underlying the sequence-to-conformation relationships of IDRs . A similar approach was pursued to uncover the roles of functional polyampholytic IDRs in p27, an inhibitor of cyclindependent kinases in yeast (Das et al., 2016) , and the IDR within the RAM region of the Notch intracellular domain that regulates transcription of Notch genes in mammalian cells (Sherry et al., 2017) .
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