Author: Nicola F Fletcher; Luke W Meredith; Emma L Tidswell; Steven R Bryden; Daniel Gonçalves-Carneiro; Yasmin Chaudhry; Claire Shannon-Lowe; Michael A Folan; Daniella A Lefteri; Marieke Pingen; Dalan Bailey; Clive S McKimmie; Alan W Baird
Title: A novel antiviral formulation inhibits a range of enveloped viruses. Document date: 2020_3_30
ID: nly9vojr_50
Snippet: To establish whether ViroSAL inhibits pseudovirus infection in other cell types, ViroSAL-treated Lassa and VSV pseudoparticles were used to infect human intestinal (Caco-2) and hepatoma (HepG2) epithelial cell monolayers. Similar levels of neutralization with ViroSAL were observed compared with that of 293T cells. The inhibition of viral infectivity with pH5.5 control treatment was perhaps due to the less efficient entry of viral pseudoparticles .....
Document: To establish whether ViroSAL inhibits pseudovirus infection in other cell types, ViroSAL-treated Lassa and VSV pseudoparticles were used to infect human intestinal (Caco-2) and hepatoma (HepG2) epithelial cell monolayers. Similar levels of neutralization with ViroSAL were observed compared with that of 293T cells. The inhibition of viral infectivity with pH5.5 control treatment was perhaps due to the less efficient entry of viral pseudoparticles to these cells compared with the highly permissive 293T cell line (Supplementary Figure 1) . Because many aspects of enveloped virus lifecycles are pH sensitive (Ruigrok et al., 1992) and pH is the most common variable when assessing the antimicrobial activity of fatty acids (Churchward et al., 2018) , in all cases the control against which ViroSAL treatments were compared were those exposed to virus at pH 5.5.
Search related documents:
Co phrase search for related documents- antimicrobial activity and cell type: 1, 2, 3, 4
- antimicrobial activity and control treatment: 1, 2, 3
- antimicrobial activity and fatty acid: 1, 2, 3, 4, 5
- cell line and common variable: 1
- cell line and control treatment: 1, 2, 3, 4, 5, 6, 7, 8
- cell line and efficient entry: 1, 2, 3, 4, 5, 6, 7
- cell line and fatty acid: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- cell line and pseudovirus infection: 1, 2, 3
- cell monolayer and control treatment: 1
- cell monolayer and epithelial cell monolayer: 1, 2
- cell type and control treatment: 1, 2, 3
- cell type and efficient entry: 1, 2
- cell type and fatty acid: 1, 2, 3, 4
- cell type and pseudovirus infection: 1, 2, 3
- cell type pseudovirus infection and pseudovirus infection: 1, 2
- common variable and control treatment: 1
- control treatment and fatty acid: 1, 2, 3, 4, 5
Co phrase search for related documents, hyperlinks ordered by date