Selected article for: "sequence function and structure function"
Author: Megan C. Cohan; Ammon E. Posey; Steven J. Grigsby; Anuradha Mittal; Alex S. Holehouse; Paul J. Buske; Petra A. Levin; Rohit V. Pappu
Title: Evolved sequence features within the intrinsically disordered tail influence FtsZ assembly and bacterial cell division
  • Document date: 2018_4_14
    • ID: 2rzfuy33_3
    Snippet: In contrast to eukaryotic systems and viruses, where the functional importance of IDRs / IDPs is reasonably well established (Berlow et al., 2017; Jensen et al., 2011; Mollica et al., 2016; Wright and Dyson, 2015) , the prevailing dogma is that bacterial proteins largely conform to the classical sequence-structure-function paradigm (Dunker et al., 2015; Pavlovic-Lazetic et al., 2011) . This view has emerged from bioinformatics analysis, which sho.....
    Document: In contrast to eukaryotic systems and viruses, where the functional importance of IDRs / IDPs is reasonably well established (Berlow et al., 2017; Jensen et al., 2011; Mollica et al., 2016; Wright and Dyson, 2015) , the prevailing dogma is that bacterial proteins largely conform to the classical sequence-structure-function paradigm (Dunker et al., 2015; Pavlovic-Lazetic et al., 2011) . This view has emerged from bioinformatics analysis, which shows that only a small percentage of bacterial proteins include long IDRs (Brown et al., 2011; Chen et al., 2006; Yruela et al., 2017) . The apparent bias against IDRs / IDPs in bacterial proteomes has been ascribed to a variety of factors. These include shorter protein lengths, the importance of well-defined structure in metabolic enzymes, and the purportedly focused / limited repertoire of functions associated with bacterial proteins (Brown et al., 2010; Dunker et al., 2001; Yruela et al., 2017) .

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