Neurological symptoms in hospitalised patients with COVID-19 and their association with in-hospital mortality.

Wnuk, Marcin; Sawczyńska, Katarzyna; Kęsek, Tomasz; Wrona, Paweł; Chatys-Bogacka, Żaneta; Mazurkiewicz, Iwona; Drabik, Leszek; Jagiełła, Jeremiasz; Szaleniec, Joanna; Czepiel, Jacek; Pawliński, Łukasz; Bień, Artur Igor; Kania, Michał; Fiema, Mateusz; Zięba-Parkitny, Joanna; Hajek, Agnes; Ucieklak, Damian; Wilk, Magdalena; Pośpiech, Kamila; Lechowicz, Patrycja; Kasprzycki, Karol; Kopka, Marianna; Hohendorff, Jerzy; Katra, Barbara; Kostrzycka, Małgorzata; Adamczyk, Michalina; Surowiec, Paulina; Rybicka, Monika; Walczewska, Jolanta; Kamińska, Barbara; Piętak, Ewelina; Bryniarski, Paweł; Marona, Monika; Motyl, Maciej; Kępińska-Wnuk, Alicja; Włodarczyk, Małgorzata; Nowak, Klaudia; Gradek-Kwinta, Elżbieta; Czyżycki, Mateusz; Dwojak, Mateusz; Rzemińska, Agnieszka; Wężyk, Kamil; Koźmiński, Wojciech; Pułyk, Agnieszka; Garlicki, Aleksander; Grodzicki, Tomasz; Małecki, Maciej; Słowik, Agnieszka

OBJECTIVES To evaluate the spectrum of neurological symptoms in patients with COVID-19 during the first 14 days of hospitalisation and its association with in-hospital mortality. MATERIAL AND METHODS We included 200 patients with RT-PCR-confirmed COVID-19 admitted to University Hospital in Krakow, Poland. In 164 patients, a detailed questionnaire concerning neurological symptoms and signs was performed prospectively within 14 days of hospitalisation. In the remaining 36 patients, such questionnaires were completed retrospectively based on daily observations in the Department of Neurology. RESULTS During hospitalisation, 169 patients (84.5%) experienced neurological symptoms; the most common were: fatigue (62.5%), decreased mood (45.5%), myalgia (43.5%), and muscle weakness (42.5%). Patients who died during hospitalisation compared to the remainder were older (79 [70.5-88.5] vs. 63.5 [51-77] years, p = 0.001), and more often had decreased level of consciousness (50.0% vs. 9.3%, p < 0.001), delirium (33.3% vs. 4.4%, p < 0.001), arterial hypotension (50.0% vs. 19.6%, p = 0.005) or stroke during (18.8% vs. 3.3%, p = 0.026) or before hospitalisation (50.0% vs. 7.1, p < 0.001), whereas those who survived more often suffered from headache (42.1% vs. 0%, p = 0.012) or decreased mood (51.7% vs. 0%, p = 0.003). CONCLUSIONS Most hospitalised patients with COVID-19 experience neurological symptoms. Decreased level of consciousness, delirium, arterial hypotension, and stroke during or before hospitalisation increase the risk of in-hospital mortality.