Author: Luo, Pan; Liu, Yi; Qiu, Lin; Liu, Xiulan; Liu, Dong; Li, Juan
Title: Tocilizumab treatment in COVIDâ€19: A single center experience Cord-id: zwpqwpry Document date: 2020_4_15
ID: zwpqwpry
Snippet: Tocilizumab (TCZ), a monoclonal antibody against interleukinâ€6 (ILâ€6), emerged as an alternative treatment for COVIDâ€19 patients with a risk of cytokine storms recently. In the present study, we aimed to discuss the treatment response of TCZ therapy in COVIDâ€19 infected patients. The demographic, treatment, laboratory parameters of Câ€reactive protein (CRP) and ILâ€6 before and after TCZ therapy and clinical outcome in the 15 COVIDâ€19 patients were retrospectively assessed. Totally 1
Document: Tocilizumab (TCZ), a monoclonal antibody against interleukinâ€6 (ILâ€6), emerged as an alternative treatment for COVIDâ€19 patients with a risk of cytokine storms recently. In the present study, we aimed to discuss the treatment response of TCZ therapy in COVIDâ€19 infected patients. The demographic, treatment, laboratory parameters of Câ€reactive protein (CRP) and ILâ€6 before and after TCZ therapy and clinical outcome in the 15 COVIDâ€19 patients were retrospectively assessed. Totally 15 patients with COVIDâ€19 were included in this study. Two of them were moderately ill, six were seriously ill and seven were critically ill. The TCZ was used in combination with methylprednisolone in eight patients. Five patients received the TCZ administration twice or more. Although TCZ treatment ameliorated the increased CRP in all patients rapidly, for the four critically ill patients who received an only single dose of TCZ, three of them (No. 1, 2, and 3) still dead and the CRP level in the rest one patient (No. 7) failed to return to normal range with a clinical outcome of disease aggravation. Serum ILâ€6 level tended to further spiked firstly and then decreased after TCZ therapy in 10 patients. A persistent and dramatic increase of ILâ€6 was observed in these four patients who failed treatment. TCZ appears to be an effective treatment option in COVIDâ€19 patients with a risk of cytokine storms. And for these critically ill patients with elevated ILâ€6, the repeated dose of the TCZ is recommended.
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