Author: Zhaoqian Su; Yinghao Wu
Title: A Multiscale and Comparative Model for Receptor Binding of 2019 Novel Coronavirus and the Implication of its Life Cycle in Host Cells Document date: 2020_2_21
ID: 535lw99y_6
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint total numbers of viruses that were captured by host cells are plotted in Figure 2b as a 1 function of simulation time. Without surprise, the figure shows that although almost all 2 viruses were attached to the cell surfaces by the end of both simulations, the kinetic 3 process in the SARS system is much fas.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.20.958272 doi: bioRxiv preprint total numbers of viruses that were captured by host cells are plotted in Figure 2b as a 1 function of simulation time. Without surprise, the figure shows that although almost all 2 viruses were attached to the cell surfaces by the end of both simulations, the kinetic 3 process in the SARS system is much faster than the 2019-nCoV system, which is resulted 4 from the difference in the association rate between receptors and their corresponding S-5 proteins. This leads into the fact that during the early stage of simulations, more SARS 6 viruses attach to host cells than 2019-nCoV. For instance, when the simulations in both 7 systems reached the first 10 5 nanoseconds, there have already been more than 40 SARS 8 viruses attached to the cell surfaces. In contrast, there were less than 20 viruses attached 9 to the cell surfaces within the same amount of time in the 2019-nCoV system.
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