Author: Subbarao, Sathyavani; Warrener, Lenesha A; Hoschler, Katja; Perry, Keith R; Shute, Justin; Whitaker, Heather; O’Brien, Michelle; Baawuah, Frances; Moss, Paul; Parry, Helen; Ladhani, Shamez N; Ramsay, Mary E; Brown, Kevin E; Amirthalingam, Gayatri
Title: Robust antibody responses in 70–80-year-olds 3 weeks after the first or second doses of Pfizer/BioNTech COVID-19 vaccine, United Kingdom, January to February 2021 Cord-id: 7xhd76fr Document date: 2021_3_25
ID: 7xhd76fr
Snippet: Sera were collected from 185 adults aged ≥ 70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in > 94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom’s approach of prioritising the first dose
Document: Sera were collected from 185 adults aged ≥ 70 years in London to evaluate the immune response to COVID-19 vaccines. A single dose of Pfizer/BioNtech vaccine resulted in > 94% seropositivity after 3 weeks in naïve individuals using the Roche Spike antibody assay, while two doses produced very high spike antibody levels, significantly higher than convalescent sera from mild-to-moderate PCR-confirmed adult cases. Our findings support the United Kingdom’s approach of prioritising the first dose and delaying the second dose of COVID-19 vaccine.
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