Author: Yong Gao; Yi Yuan; Tuan Tuan Li; Wu Xiao Wang; Yong Xiu Li; Ang Li; Feng Ming Han
Title: Evaluation the auxiliary diagnosis value of antibodies assays for detection of novel coronavirus (SARS-Cov-2) causing an outbreak of pneumonia (COVID-19) Document date: 2020_3_30
ID: 8mx5kowl_2
Snippet: The use of quantitative real-time PCR (qRT-PCR) assays for the detection of the viral nucleic acid has become the primary and crucial diagnostic approach for identification of SARS-CoV-2 infection, while it still has some limitations in clinical practice (7) (8) (9) . The RNA-based diagnostic tests only give a positive result when the virus is still present. The tests could not identify people who has been infected in the past, recovered, and cle.....
Document: The use of quantitative real-time PCR (qRT-PCR) assays for the detection of the viral nucleic acid has become the primary and crucial diagnostic approach for identification of SARS-CoV-2 infection, while it still has some limitations in clinical practice (7) (8) (9) . The RNA-based diagnostic tests only give a positive result when the virus is still present. The tests could not identify people who has been infected in the past, recovered, and cleared the virus from their bodies. In addition, negligible false-negative risk brought by PCR test were reported and the positive rates varied for different specimens in COVID-19 patients. A number of cases that were epidemiologically linked to SARS-CoV-2 exposure and with typical lung CT images still remained RNA negative in their respiratory tract specimens(10-12).
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