Selected article for: "LRTI respiratory tract infection and Upper URTI respiratory tract infection"
Author: Jacobs, Samantha E.; Lamson, Daryl M.; Soave, Rosemary; Guzman, Brigitte Huertas; Shore, Tsiporah B.; Ritchie, Ellen K.; Zappetti, Dana; Satlin, Michael J.; Leonard, John P.; van Besien, Koen; Schuetz, Audrey N.; Jenkins, Stephen G.; St George, Kirsten; Walsh, Thomas J.
Title: Clinical and Molecular Epidemiology of Human Rhinovirus Infections in Patients with Hematologic Malignancy
  • Cord-id: gzjxqfa8
  • Document date: 2015_10_1
    • ID: gzjxqfa8
    Snippet: BACKGROUND: Human rhinoviruses (HRVs) are common causes of upper respiratory tract infection (URTI) in hematologic malignancy (HM) patients. Predictors of lower respiratory tract infection (LRTI) including the impact of HRV species and types are poorly understood. OBJECTIVES: This study aims to describe the clinical and molecular epidemiology of HRV infections among HM patients. STUDY DESIGN: From April 2012–March 2013, HRV-positive respiratory specimens from symptomatic HM patients were molec
    Document: BACKGROUND: Human rhinoviruses (HRVs) are common causes of upper respiratory tract infection (URTI) in hematologic malignancy (HM) patients. Predictors of lower respiratory tract infection (LRTI) including the impact of HRV species and types are poorly understood. OBJECTIVES: This study aims to describe the clinical and molecular epidemiology of HRV infections among HM patients. STUDY DESIGN: From April 2012–March 2013, HRV-positive respiratory specimens from symptomatic HM patients were molecularly characterized by analysis of partial viral protein 1 (VP1) or VP4 gene sequence. HRV LRTI risk-factors and outcomes were analyzed using multivariable logistic regression. RESULTS: One hundred and ten HM patients presented with HRV URTI (n=78) and HRV LRTI (n=32). Hypoalbuminemia (OR 3.0; 95% CI, 1.0 – 9.2; p=0.05) was independently associated with LRTI, but other clinical and laboratory markers of host immunity did not differ between patients with URTI versus LRTI. Detection of bacterial co-pathogens was common in LRTI cases (25%). Among 92 typeable respiratory specimens, there were 58 (64%) HRV-As, 12 (13%) HRV-Bs, and 21 (23%) HRV-Cs, and one Enterovirus 68. LRTI rates among HRV-A (29%), HRV-B (17%), and HRV-C (29%) were similar. HRV-A infections occurred year-round while HRV-B and HRV-C infections clustered in the late fall and winter. CONCLUSIONS: HRVs are associated with LRTI in HM patients. Illness severity is not attributable to specific HRV species or types. The frequent detection of bacterial co-pathogens in HRV LRTIs further substantiates the hypothesis that HRVs predispose to bacterial superinfection of the lower airways, similar to that of other community-acquired respiratory viruses.

    Search related documents:
    Co phrase search for related documents
    • absolute difference and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
    • absolute difference and low number: 1
    • absolute frequency and acute leukemia: 1
    • absolute frequency and logistic regression: 1, 2, 3
    • acid fast bacillus and logistic regression: 1
    • acute leukemia and adaptive innate: 1, 2
    • acute leukemia and logistic regression: 1, 2, 3, 4
    • acute reason and adaptive innate: 1
    • acute reason and additional study: 1
    • acute reason and logistic regression: 1, 2, 3, 4
    • acute respiratory illness and adaptive innate: 1, 2, 3
    • acute respiratory illness and additional study: 1
    • acute respiratory illness and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute routine and additional study: 1
    • acute routine and logistic regression: 1
    • adaptive innate and additional study: 1
    • adaptive innate and logistic regression: 1, 2, 3, 4, 5, 6, 7, 8
    • adaptive innate and low cytokine: 1
    • adaptive innate and low number: 1, 2, 3, 4