Author: Stuart Weston; Rob Haupt; James Logue; Krystal Matthews; Matthew B. Frieman
Title: FDA approved drugs with broad anti-coronaviral activity inhibit SARS-CoV-2 in vitro Document date: 2020_3_27
ID: jbc74lcu_18
Snippet: SARS-CoV-2 production was more sensitive to hydroxychloroquine with larger inhibition seen at the same concentration of treatment, which is in agreement with hydroxychloroquine having a lower IC50 in our cell viability assay (Table 1) . Overall, these data demonstrates that hydroxychloroquine and chloroquine phosphate inhibit cytopathic effect, synthesis of viral mRNA and production of infectious SARS-CoV-2 particles in vitro......
Document: SARS-CoV-2 production was more sensitive to hydroxychloroquine with larger inhibition seen at the same concentration of treatment, which is in agreement with hydroxychloroquine having a lower IC50 in our cell viability assay (Table 1) . Overall, these data demonstrates that hydroxychloroquine and chloroquine phosphate inhibit cytopathic effect, synthesis of viral mRNA and production of infectious SARS-CoV-2 particles in vitro.
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