Author: Shitao Rao; Alexandria Lau; Hon-Cheong So
Title: Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of 2019-nCov: A Mendelian Randomization analysis Document date: 2020_3_8
ID: myh73pe6_31
Snippet: Regarding the effect size of casual associations, since the exposures were binary, the regression coefficients (beta) from MR may be roughly interpreted as average change in the outcome (increase in normalized expression level) per 2.72-fold increase in the prevalence of the exposure 34 . For type II diabetes, or self-reported diabetes from UKBB which presumably comprised mainly type II diabetes, the causal estimates ranged from ~0.1621 to 0.1835.....
Document: Regarding the effect size of casual associations, since the exposures were binary, the regression coefficients (beta) from MR may be roughly interpreted as average change in the outcome (increase in normalized expression level) per 2.72-fold increase in the prevalence of the exposure 34 . For type II diabetes, or self-reported diabetes from UKBB which presumably comprised mainly type II diabetes, the causal estimates ranged from ~0.1621 to 0.1835. These estimates were reasonably close despite different datasets being used.
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