Selected article for: "bat virus and pangolin virus"
Author: Maciej F Boni; Philippe Lemey; Xiaowei Jiang; Tommy Tsan-Yuk Lam; Blair Perry; Todd Castoe; Andrew Rambaut; David L Robertson
Title: Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic
  • Document date: 2020_3_31
    • ID: h2uc7ria_13
    Snippet: As the SARS-CoV-2 S protein has been implicated in past recombination events or possibly convergent evolution (Lam et al., 2020) , we specifically investigated several sub-regions of the S proteinthe N-terminal domain of S1, the C-terminal domain of S1, the variable loop region of the C-terminal domain, and S2. The variable loop region in SARS-CoV-2 shows closer identity to the 2019 pangolin coronavirus sequence than to the RaTG13 bat virus, supp.....
    Document: As the SARS-CoV-2 S protein has been implicated in past recombination events or possibly convergent evolution (Lam et al., 2020) , we specifically investigated several sub-regions of the S proteinthe N-terminal domain of S1, the C-terminal domain of S1, the variable loop region of the C-terminal domain, and S2. The variable loop region in SARS-CoV-2 shows closer identity to the 2019 pangolin coronavirus sequence than to the RaTG13 bat virus, supported by phylogenetic inference (Figure 3 ). On first examination this would suggest that that SARS-CoV-2 is a recombinant of an ancestor of Pangolin-2019 and RaTG13.

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