Author: Shitao Rao; Alexandria Lau; Hon-Cheong So
Title: Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of 2019-nCov: A Mendelian Randomization analysis Document date: 2020_3_8
ID: myh73pe6_2
Snippet: A number of studies have looked into the relationship between ACE2 expression level and coronavirus infection. For example, Li et al. overexpressed ACE2 protein in 293T and Vero E6 cell lines. Over-expression of ACE2 lead to more efficient viral replication, but it was blocked by anti-ACE2 antibody in a dose-dependent manner 9 . A further study also confirmed that susceptibility to SAR-CoV correlates with ACE2 expression on cell lines 13 . In a s.....
Document: A number of studies have looked into the relationship between ACE2 expression level and coronavirus infection. For example, Li et al. overexpressed ACE2 protein in 293T and Vero E6 cell lines. Over-expression of ACE2 lead to more efficient viral replication, but it was blocked by anti-ACE2 antibody in a dose-dependent manner 9 . A further study also confirmed that susceptibility to SAR-CoV correlates with ACE2 expression on cell lines 13 . In a subsequent work, Jia et al. showed that undifferentiated airway epithelial cells that express little ACE2 were poorly infected by SARS-CoV, while well-differential cells expressing higher ACE2 were readily infected 14 . Taking the evidence together, expression level of the ACE2 protein is associated with susceptibility to SARS-CoV infection.
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