Author: Zhang, Renli; Guo, Zhongmin; Lu, Jiahai; Meng, Jinxiu; Zhou, Canquan; Zhan, Ximei; Huang, Bing; Yu, Xinbing; Huang, Min; Pan, Xinghua; Ling, Wenhua; Chen, Xigu; Wan, Zhuoyue; Zheng, Huanying; Yan, Xinge; Wang, Yifei; Ran, Yanchao; Liu, Xinjian; Ma, Junxin; Wang, Chengyu; Zhang, Biliang
Title: Inhibiting severe acute respiratory syndrome-associated coronavirus by small interfering RNA. Cord-id: 3p5zsecv Document date: 2003_1_1
ID: 3p5zsecv
Snippet: OBJECTIVE To evaluate the effectiveness of small interfering RNA (siRNA) on inhibiting severe acute respiratory syndrome (SARS)-associated coronavirus replication, and to lay bases for the future clinical application of siRNA for the treatment of viral infectious diseases. METHODS Vero-E6 cells was transfected with siRNA before SARS virus infection, and the effectiveness of siRNA interference was evaluated by observing the cytopathic effect (CPE) on Vero-E6 cells. RESULTS Five pairs of siRNA sho
Document: OBJECTIVE To evaluate the effectiveness of small interfering RNA (siRNA) on inhibiting severe acute respiratory syndrome (SARS)-associated coronavirus replication, and to lay bases for the future clinical application of siRNA for the treatment of viral infectious diseases. METHODS Vero-E6 cells was transfected with siRNA before SARS virus infection, and the effectiveness of siRNA interference was evaluated by observing the cytopathic effect (CPE) on Vero-E6 cells. RESULTS Five pairs of siRNA showed ability to reduce CPE dose dependently, and two of them had the best effect. CONCLUSION siRNA may be effective in inhibiting SARS-associated coronavirus replication.
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