Selected article for: "cholesterol level and elevated expression"
Author: Shitao Rao; Alexandria Lau; Hon-Cheong So
Title: Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of 2019-nCov: A Mendelian Randomization analysis
  • Document date: 2020_3_8
    • ID: myh73pe6_34
    Snippet: As shown in Table 1 , a number of other disease/traits also showed (nominally) significant results. Several neoplasms, such as breast and lung cancer, may be associated with increased ACE2 expression. We also observed that several autoimmune disorders, especially inflammatory bowel diseases may be casually associated with ACE2 expression. Interestingly, asthma and tobacco use also showed nominal significant associations with higher ACE2 expressio.....
    Document: As shown in Table 1 , a number of other disease/traits also showed (nominally) significant results. Several neoplasms, such as breast and lung cancer, may be associated with increased ACE2 expression. We also observed that several autoimmune disorders, especially inflammatory bowel diseases may be casually associated with ACE2 expression. Interestingly, asthma and tobacco use also showed nominal significant associations with higher ACE2 expression. As for other traits, high alanine aminotransferase (ALT), commonly associated with liver diseases, may be related to elevated ACE2 expression. Other commonly measured blood measures that may lead to altered ACE2 expression also included red cell distribution width (often associated with iron-deficiency, folate or B12 deficiency anemia), basophil percentage (inverse relationship), calcium level, urate level, HDL-cholesterol and LDL cholesterol (inverse relationship).

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