Author: Shitao Rao; Alexandria Lau; Hon-Cheong So
Title: Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of 2019-nCov: A Mendelian Randomization analysis Document date: 2020_3_8
ID: myh73pe6_56
Snippet: The drugs we highlighted in this study may help researchers to prioritize repositioning candidates for further studies, given the huge cost in developing a brand-new drug and that detailed investigations on every existing mediation will be impractical. We briefly discuss a few drugs highlighted by our analysis. Fostamatinib targets the largest number (seven) of proteins potentially linked to ACE2 expression. According to DrugBank, it serves as an.....
Document: The drugs we highlighted in this study may help researchers to prioritize repositioning candidates for further studies, given the huge cost in developing a brand-new drug and that detailed investigations on every existing mediation will be impractical. We briefly discuss a few drugs highlighted by our analysis. Fostamatinib targets the largest number (seven) of proteins potentially linked to ACE2 expression. According to DrugBank, it serves as an inhibitor for all these proteins, and all were linked to elevated ACE2 expression in the present MR analysis except one. This drug has been approved for treating Immune Thrombocytopenic Purpura (ITP), and is a spleen tyrosine kinase inhibitor 42 . There has been trials on rheumatoid arthritis (RA) 43 and IgA nephropathy as well 42 .
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