Imperial Satiety Protocol - a new non-surgical weight-loss programme, delivered in a healthcare setting, produces improved clinical outcomes for people with obesity.

Hameed, Saira; Salem, Victoria; Al-Essimii, Haya; Scholtz, Samantha; Dar, Owais; Miras, Alexander D; Meeran, Karim; Bloom, Stephen R; Ahmed, Ahmed R; Purkayastha, Sanjay; Chahal, Harvinder; Tan, Tricia

"Imperial Satiety Protocol" (I-SatPro) is a new multi-faceted approach to weight-loss for people with obesity (PwO), encompassing dietary advice, time restricted eating, physical activity, and coaching to support behaviour change. Participants (n = 84) attended fortnightly I-SatPro group sessions for 30 weeks, with 70% of participants completing. On completion at 30 weeks, the mean weight-loss was 15.2 ± 1.1 kg (13.2 ± 0.8% from baseline, p < 0.0001), which was maintained to 52 weeks (16.6 ± 1.5 kg, 14.1 ± 1.2%, p < 0.0001). Weight-loss was not associated with reduced energy expenditure. In participants with type 2 diabetes and pre-diabetes (n = 16), HbA1c fell from 50 to 43 mmol/mol (p < 0.01). Systolic blood pressure fell by 12 mmHg (p < 0.0001). Triglycerides fell by 0.37 mmol/L (p < 0.01) and HDL rose by 0.08 mmol/L (p < 0.01). Short Form-36 (SF-36) functioning and wellbeing scores increased in all domains post I-SatPro intervention. For selected PwO, I-SatPro delivers clinically meaningful weight-loss, and the potential for long-term health and wellbeing improvements. This article is protected by copyright. All rights reserved.