Author: Amir Saberi; Anastasia A. Gulyaeva; John L. Brubacher; Phillip A. Newmark; Alexander E. Gorbalenya
Title: A planarian nidovirus expands the limits of RNA genome size Document date: 2018_4_11
ID: gwgflckq_18
Snippet: The PSCNV putative 3CLpro domain is expected (31) to release itself and all downstream polyprotein components up to the border between the ORF1b-and 3'ORFs-like regions (Fig. 1C) . The polyprotein region processed by 3CLpro, and its flanking regions, are of comparable sizes (5006 vs 4400 and 4150 aa), suggesting further posttranslational processing. Indeed, we have identified a number of candidate cleavage sites for host furinlike proteases (Fig.....
Document: The PSCNV putative 3CLpro domain is expected (31) to release itself and all downstream polyprotein components up to the border between the ORF1b-and 3'ORFs-like regions (Fig. 1C) . The polyprotein region processed by 3CLpro, and its flanking regions, are of comparable sizes (5006 vs 4400 and 4150 aa), suggesting further posttranslational processing. Indeed, we have identified a number of candidate cleavage sites for host furinlike proteases (Fig. S4) , commonly involved in processing viral glycoprotein precursors (48) (SI Text).
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