Author: Zarifian, Ahmadreza; Zamiri Bidary, Mohammad; Arekhi, Soheil; Rafiee, Mahdi; Gholamalizadeh, Hanieh; Amiriani, Amirhosein; Ghaderi, Mohammad Sajjad; Khademâ€Rezaiyan, Majid; Amini, Mahnaz; Ganji, Azita
Title: Gastrointestinal and hepatic abnormalities in patients with confirmed COVIDâ€19: A systematic review and metaâ€analysis Cord-id: k5c7nirf Document date: 2020_7_27
ID: k5c7nirf
Snippet: Although not common, gastrointestinal and liver symptoms have reportedly been the initial presentation of coronavirus diseaseâ€2019 (COVIDâ€19) in a large group of patients. Therefore, knowing the frequency and characteristics of these manifestations of COVIDâ€19 is important for both clinicians and health policy makers. A systematic review and metaâ€analysis of the available data on the gastrointestinal and liver manifestations of patients with COVIDâ€19 was performed. PubMed and Scopus da
Document: Although not common, gastrointestinal and liver symptoms have reportedly been the initial presentation of coronavirus diseaseâ€2019 (COVIDâ€19) in a large group of patients. Therefore, knowing the frequency and characteristics of these manifestations of COVIDâ€19 is important for both clinicians and health policy makers. A systematic review and metaâ€analysis of the available data on the gastrointestinal and liver manifestations of patients with COVIDâ€19 was performed. PubMed and Scopus databases and Google Scholar search engine were searched for published and unpublished preprint articles up to 10 April 2020. Original studies providing information on clinical digestive symptoms or biomarkers of liver function in patients with polymerase chain reaction confirmed diagnosis of COVIDâ€19 were included. After quality appraisal, data were extracted. Prevalence data from individual studies were pooled using a randomâ€effects model. Overall, 67 studies were included in this systematic review and metaâ€analysis, comprising a pooled population of 13 251 patients with confirmed COVIDâ€19. The most common gastrointestinal symptoms were anorexia (10.2%, 95% confidence interval [CI] = 6.2%â€16.4%), diarrhea (8.4%, 95% CI = 6.2%â€11.2%), and nausea (5.7%, 95% CI = 3.7%â€8.6%), respectively. Decreased albumin levels (39.8%, 95% CI = 15.3%â€70.8%), increased aspartate aminotransferase (22.8%, 95% CI = 18.1%â€28.4%), and alanine aminotransferase (20.6%, 95% CI = 16.7%â€25.1%) were common hepatic findings. After adjusting for preexisting gastrointestinal (5.9%) and liver diseases (4.2%), the most common gastrointestinal findings were diarrhea (8.7%, 95% CI = 5.4%â€13.9%), anorexia (8.0%, 95% CI = 3.0%â€19.8%), and nausea (5.1%, 95% CI = 2.2%â€14.3%). Gastrointestinal and liver manifestations are not rare in patients with COVIDâ€19, but their prevalence might be affected by preexisting diseases. Diarrhea and mild liver abnormalities seem to be relatively common in COVIDâ€19, regardless of comorbidities
Search related documents:
Co phrase search for related documents- abdominal distension and acute respiratory syndrome: 1, 2, 3, 4, 5
- abdominal distension and liver function: 1, 2
- abdominal pain and abnormal liver function: 1, 2, 3, 4, 5, 6
- abdominal pain and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- abdominal pain and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- abdominal pain and liver gastrointestinal: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- abdominal pain and liver gastrointestinal disease: 1, 2
- abdominal pain and liver gastrointestinal tract: 1, 2, 3
- abdominal pain and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- abdominal pain diarrhea and abnormal liver function: 1, 2, 3
- abdominal pain diarrhea and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68
- abdominal pain diarrhea and liver function: 1, 2, 3, 4, 5, 6, 7, 8
- abdominal pain diarrhea and liver gastrointestinal: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- abdominal pain diarrhea and liver gastrointestinal disease: 1
- abdominal pain diarrhea and liver gastrointestinal tract: 1
- abdominal pain diarrhea and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- abdominal pain vomiting and abnormal liver function: 1, 2, 3, 4
- abdominal pain vomiting and acute respiratory syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- abdominal pain vomiting and liver function: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
Co phrase search for related documents, hyperlinks ordered by date