Author: Monika Abedin Sigg; Tabea Menchen; Jeffery Johnson; Chanjae Lee; Semil P. Choksi; Galo Garcia; Henriette Busengdal; Gerard Dougherty; Petra Pennekamp; Claudius Werner; Fabian Rentzsch; Nevan Krogan; John B. Wallingford; Heymut Omran; Jeremy F. Reiter
Title: Evolutionary proteomics uncovers ciliary signaling components Document date: 2017_6_22
ID: 9y8r277c_42
Snippet: We analyzed visceral organ placement in adult Enkur -/mice and found that 26% 421 displayed abnormal situs ( Figure 6G and H). Half of the affected mice had situs inversus totalis, 422 a complete reversal of the left-right axis, and half displayed situs ambiguus, a variably abnormal 423 positioning of organs that includes misorientation of the heart, right-sided stomach or spleen, 424 asplenia, left-sided liver, and abnormal hepatic lobulation. E.....
Document: We analyzed visceral organ placement in adult Enkur -/mice and found that 26% 421 displayed abnormal situs ( Figure 6G and H). Half of the affected mice had situs inversus totalis, 422 a complete reversal of the left-right axis, and half displayed situs ambiguus, a variably abnormal 423 positioning of organs that includes misorientation of the heart, right-sided stomach or spleen, 424 asplenia, left-sided liver, and abnormal hepatic lobulation. Embryos that lack nodal cilia or have 425 non-motile nodal cilia exhibit a higher incidence of abnormal situs than do Enkur -/embryos 426 (Nonaka et al., 1998; Takeda et al., 1999) . The presence of left-right axis defects in a minority of 427
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