Author: Schwarz, Silvia; Wang, Kai; Yu, Wenjing; Sun, Bing; Schwarz, Wolfgang
Title: Emodin inhibits current through SARS-associated coronavirus 3a protein Cord-id: 9hvojcnk Document date: 2011_2_26
ID: 9hvojcnk
Snippet: The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as viru
Document: The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K(1/2) value of about 20 μM. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents.
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