Author: Barros-Martins, J.; Hammerschmidt, S.; Cossmann, A.; Odak, I.; Stankov, M. V.; Morillas Ramos, G.; Jablonka, A.; Heidemann, A.; Ritter, C.; Friedrichsen, M.; Schultze-Florey, C. R.; Ravens, I.; Stefanie, W.; Bubke, A.; Ristenpart, J.; Janssen, A.; Ssebyatika, G.; Bernhardt, G.; Muench, J. R.; Hoffmann, M.; Poehlmann, S.; Krey, T.; Bosnjak, B.; Foerster, R.; Behrens, G. M.
Title: Humoral and cellular immune response against SARS-CoV-2 variants following heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination. Cord-id: inc72u8j Document date: 2021_6_3
ID: inc72u8j
Snippet: Cerebral venous thrombosis was reported as a rare but serious adverse event in young and middle-aged vaccinees following immunization with AstraZeneca's ChAdOx1-nCov-19 vaccine. As a consequence, several European governments recommended using this vaccine only in individuals older than 60 years leaving millions of ChAd primed individuals with the decision to either receive a second shot of ChAd or a heterologous boost with mRNA-based vaccines. However, such combinations have not been tested so f
Document: Cerebral venous thrombosis was reported as a rare but serious adverse event in young and middle-aged vaccinees following immunization with AstraZeneca's ChAdOx1-nCov-19 vaccine. As a consequence, several European governments recommended using this vaccine only in individuals older than 60 years leaving millions of ChAd primed individuals with the decision to either receive a second shot of ChAd or a heterologous boost with mRNA-based vaccines. However, such combinations have not been tested so far. We used Hannover Medical School's COVID-19 Contact (CoCo) Study cohort of health care professionals (HCP) to monitor ChAd primed immune responses before and three weeks after booster with ChAd or BioNTech/Pfizer's BNT162b2. Whilst both vaccines boosted prime-induced immunity, BNT induced significantly higher frequencies of Spike-specific CD4 and CD8 T cells and, in particular, high titers of neutralizing antibodies against the B.1.1.7, B.1.351 and the P.1 variants of concern of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2).
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