Author: Qiang Huang; Andreas Herrmann
Title: Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV) Document date: 2020_2_3
ID: eecyduzq_4
Snippet: It is widely accepted that the CoV human transmission is driven by the interactions of its trimeric transmembrane spike glycoprotein (S-protein) with the human receptors on the host cell surface. The S-protein consists of two subunits (i.e., S1 and S2) and is essential for the early steps of host cell infection: S-protein of a virion binds to the host cell receptors via its S1 receptor-binding domain (S-RBD) and then fuses the viral membrane with.....
Document: It is widely accepted that the CoV human transmission is driven by the interactions of its trimeric transmembrane spike glycoprotein (S-protein) with the human receptors on the host cell surface. The S-protein consists of two subunits (i.e., S1 and S2) and is essential for the early steps of host cell infection: S-protein of a virion binds to the host cell receptors via its S1 receptor-binding domain (S-RBD) and then fuses the viral membrane with cellular membranes. The host cell receptors differ among human CoVs: SARS-CoV binds to exopeptidase angiotensin-converting enzyme 2 (ACE2) (Li et al., 2005; Li et al., 2003) , and MERS-CoV to dipeptidyl peptidase 4(DPP4) (Raj et al., 2013) ; other CoVs such as HCoV-HKU1 use O-acetylated sialic acid as a receptor (Huang et al., 2015) .
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