Selected article for: "cell invasion and tumor cell invasion"
Author: Pfirschke, Christina; Engblom, Camilla; Gungabeesoon, Jeremy; Lin, Yunkang; Rickelt, Steffen; Zilionis, Rapolas; Messemaker, Marius; Siwicki, Marie; Gerhard, Genevieve M.; Kohl, Anna; Meylan, Etienne; Weissleder, Ralph; Klein, Allon M.; Pittet, Mikael J.
Title: Tumor-Promoting Ly-6G(+) SiglecF(high) Cells Are Mature and Long-Lived Neutrophils
  • Cord-id: b2q4icii
  • Document date: 2020_9_22
    • ID: b2q4icii
    Snippet: Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some of these cells’ fundamental features remain unexplored. Here, we show that tumor-infiltrating CD11b(+) Ly-6G(+) SiglecF(high) cells are bona fide mature neutrophils and therefore differ from other myeloid cells, including SiglecF(high) eosinophils, SiglecF(
    Document: Myeloid cells co-expressing the markers CD11b, Ly-6G, and SiglecF can be found in large numbers in murine lung adenocarcinomas and accelerate cancer growth by fostering tumor cell invasion, angiogenesis, and immunosuppression; however, some of these cells’ fundamental features remain unexplored. Here, we show that tumor-infiltrating CD11b(+) Ly-6G(+) SiglecF(high) cells are bona fide mature neutrophils and therefore differ from other myeloid cells, including SiglecF(high) eosinophils, SiglecF(high) macrophages, and CD11b(+) Ly-6G(+) myeloid-derived suppressor cells. We further show that SiglecF(high) neutrophils gradually accumulate in growing tumors, where they can live for several days; this lifespan is in marked contrast to that of their SiglecF(low) counterparts and neutrophils in general, which live for several hours only. Together, these findings reveal distinct attributes for tumor-promoting SiglecF(high) neutrophils and help explain their deleterious accumulation in the tumor bed.

    Search related documents:
    Co phrase search for related documents
    • low density and lung adenocarcinoma cell: 1
    • low density and lung blood: 1, 2, 3, 4
    • low density and lung neutrophil: 1, 2, 3, 4
    • low density and lung tissue: 1, 2, 3, 4, 5, 6, 7
    • low density and lysis buffer: 1
    • low density and macrophage differentiation: 1
    • low density high and lung adenocarcinoma: 1
    • low density high and lung adenocarcinoma cell: 1
    • low density high and lung blood: 1
    • low density high and lung tissue: 1