Author: Kim-Hellmuth, Sarah; Hermann, Matthias; Eilenberger, Julia; Ley-Zaporozhan, Julia; Fischer, Marcus; Hauck, Fabian; Klein, Christoph; Haas, Nikolaus; Kappler, Matthias; Huebner, Johannes; Jakob, André; von Both, Ulrich
Title: SARS-CoV-2 triggering severe ARDS and secondary HLH in a 3-year-old child with Down syndrome Cord-id: klcw6k9u Document date: 2020_11_14
ID: klcw6k9u
Snippet: Down syndrome (DS) predisposes to severe immunologic reaction secondary to infectious triggers. Here we report a paediatric DS patient with COVID-19 who developed a hyperinflammatory syndrome, severe ARDS and secondary HLH requiring PICU admission and treatment with steroids, IVIG and Remdesivir. Investigations into genetic susceptibilities for COVID-19 and SARS-CoV-2-associated complications warrants systematic clinical and scientific studies.
Document: Down syndrome (DS) predisposes to severe immunologic reaction secondary to infectious triggers. Here we report a paediatric DS patient with COVID-19 who developed a hyperinflammatory syndrome, severe ARDS and secondary HLH requiring PICU admission and treatment with steroids, IVIG and Remdesivir. Investigations into genetic susceptibilities for COVID-19 and SARS-CoV-2-associated complications warrants systematic clinical and scientific studies.
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