Selected article for: "false negative and low quality"
Author: Ingrid Arevalo-Rodriguez; Diana Buitrago-Garcia; Daniel Simancas-Racines; Paula Zambrano-Achig; Rosa del Campo; Agustin Ciapponi; Omar Sued; Laura Martinez-Garcia; Anne Rutjes; Nicola Low; Jose A Perez-Molina; Javier Zamora
Title: FALSE-NEGATIVE RESULTS OF INITIAL RT-PCR ASSAYS FOR COVID-19: A SYSTEMATIC REVIEW
  • Document date: 2020_4_21
    • ID: g8h6trql_45
    Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10. 1101 findings for RT-PCR and chest CT) from several provinces of China and collected between January to 267 February 2020. We considered all studies to be affected by several sources of bias, especially related 268 to the independence between the index test and the reference standard and the unclear report of 269 key RT-PCR characteristics. A meta-an.....
    Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10. 1101 findings for RT-PCR and chest CT) from several provinces of China and collected between January to 267 February 2020. We considered all studies to be affected by several sources of bias, especially related 268 to the independence between the index test and the reference standard and the unclear report of 269 key RT-PCR characteristics. A meta-analysis of the proportions using Stata® showed a considerable 270 heterogeneity not explained by the collected data, and this variability is a limitation for the full 271 interpretation of averaged proportion. As an alternative, we preferred to provide an analysis of the 272 range of false-negative proportions derived from included studies in a cohort of 100 patients tested 273 and using three different prevalence of the disease derived from the current clinical practice of our 274 participant stakeholders. Using a prevalence of 80%, we found that 2 to 23 cases would be 275 misdiagnosed and then they could no receive adequate clinical management. However, we 276 emphasized that this numerical approach should be interpreted with caution due to the multiple 277 limitations of the evidence described above (Quality of evidence: Very low). 278

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