Author: Qiang Huang; Andreas Herrmann
Title: Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV) Document date: 2020_2_3
ID: eecyduzq_3
Snippet: In December 2019, a novel CoV (2019-nCoV) emerged from Wuhan, China, and spread rapidly to other areas (Holshue et al., 2020; Li et al., 2020; Wu et al., 2020; Zhou et al., 2020) . Although its original host remains unknown, all available data point again to a wild animal source. And, it is evident that human-to-human transmission is causing the rapid spreading of this newly emerged virus. Viral strains from infected persons of the area have been.....
Document: In December 2019, a novel CoV (2019-nCoV) emerged from Wuhan, China, and spread rapidly to other areas (Holshue et al., 2020; Li et al., 2020; Wu et al., 2020; Zhou et al., 2020) . Although its original host remains unknown, all available data point again to a wild animal source. And, it is evident that human-to-human transmission is causing the rapid spreading of this newly emerged virus. Viral strains from infected persons of the area have been sequenced; but only little genetic variation was found, implying that they are descended from a common ancestor (Rambaut, 2020) . Full-length genome analysis of 2019-nCoV patient samples revealed 79.5% and 96% sequence identities to SARS-CoV and a bat SARSr-Cov (severe acute respiratory syndrome-related CoV), respectively; however, sequences of the seven conserved viral replicase domains in ORF1ab show 94.6% identity between 2019-nCoV and SARS-CoV .
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