Author: Rioux, Melissa; Francis, Magen E.; Swan, Cynthia L.; Ge, Anni; Kroeker, Andrea; Kelvin, Alyson A.
Title: The Intersection of Age and Influenza Severity: Utility of Ferrets for Dissecting the Age-Dependent Immune Responses and Relevance to Age-Specific Vaccine Development Cord-id: d7zqincw Document date: 2021_4_15
ID: d7zqincw
Snippet: Many factors impact the host response to influenza virus infection and vaccination. Ferrets have been an indispensable reagent for influenza virus research for almost one hundred years. One of the most significant and well-known factors affecting human disease after infection is host age. Another significant factor is the virus, as strain-specific disease severity is well known. Studying age-related impacts on viral infection and vaccination outcomes requires an animal model that reflects both t
Document: Many factors impact the host response to influenza virus infection and vaccination. Ferrets have been an indispensable reagent for influenza virus research for almost one hundred years. One of the most significant and well-known factors affecting human disease after infection is host age. Another significant factor is the virus, as strain-specific disease severity is well known. Studying age-related impacts on viral infection and vaccination outcomes requires an animal model that reflects both the physiological and immunological changes that occur with human aging, and sensitivity to differentially virulent influenza viruses. The ferret is uniquely susceptible to a plethora of influenza viruses impacting humans and has proven extremely useful in studying the clinical and immunological pictures of influenza virus infection. Moreover, ferrets developmentally have several of the age-related physiological changes that occur in humans throughout infancy, adulthood, old age, and pregnancy. In this review, we discuss ferret susceptibility to influenza viruses, summarize previous influenza studies using ferrets as models of age, and finally, highlight the application of ferret age models in the pursuit of prophylactic and therapeutic agents to address age-related influenza disease severity.
Search related documents:
Co phrase search for related documents- accurate modeling and acute respiratory disease syndrome: 1
- accurate quantification and activity level: 1
- accurate quantification and acute coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9
- accurate quantification and acute respiratory disease syndrome: 1, 2, 3
- activity level and acute coronavirus: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- activity level and acute respiratory disease syndrome: 1, 2, 3, 4, 5, 6, 7, 8, 9
- activity level and acute respiratory disease syndrome ards: 1
- activity level and adaptive immune system: 1
- activity level and additional study: 1
- acute coronavirus and adaptive immune gene: 1
- acute coronavirus and adaptive immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute coronavirus and additional group: 1, 2, 3, 4, 5, 6, 7
- acute coronavirus and additional study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19
- acute coronavirus and additional work: 1, 2, 3, 4, 5
- acute respiratory disease syndrome and adaptive immune gene: 1
- acute respiratory disease syndrome and adaptive immune system: 1, 2, 3, 4, 5, 6, 7, 8
- acute respiratory disease syndrome and additional group: 1, 2
- acute respiratory disease syndrome and additional mode: 1
- acute respiratory disease syndrome and additional study: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
Co phrase search for related documents, hyperlinks ordered by date