Author: Qiang Huang; Andreas Herrmann
Title: Fast assessment of human receptor-binding capability of 2019 novel coronavirus (2019-nCoV) Document date: 2020_2_3
ID: eecyduzq_5
Snippet: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https: //doi.org/10.1101 //doi.org/10. /2020 Sequence alignment of S1-proteins has revealed a sequence identity of about 75% between that of 2019-nCoV and those of several other CoVs including SARS-CoV . Comparing with that of SARS-CoV, the S-RBD sequence of 2019-nCoV S-protein is very c.....
Document: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https: //doi.org/10.1101 //doi.org/10. /2020 Sequence alignment of S1-proteins has revealed a sequence identity of about 75% between that of 2019-nCoV and those of several other CoVs including SARS-CoV . Comparing with that of SARS-CoV, the S-RBD sequence of 2019-nCoV S-protein is very conserved, implying that ACE2 is the specific receptor for this virus to bind to the human host cells (Lu et al., 2020; Xu et al., 2020) . Indeed, recent experimental evidences also supported that ACE2 is the human receptor of 2019-nCoV . Consequently, it becomes very interesting to characterize the human receptor-binding capability of 2019-nCoV by analyzing the S-protein interactions with ACE2, in order to assess its potential for the human-to-human transmission.
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