Author: Ingrid Arevalo-Rodriguez; Diana Buitrago-Garcia; Daniel Simancas-Racines; Paula Zambrano-Achig; Rosa del Campo; Agustin Ciapponi; Omar Sued; Laura Martinez-Garcia; Anne Rutjes; Nicola Low; Jose A Perez-Molina; Javier Zamora
Title: FALSE-NEGATIVE RESULTS OF INITIAL RT-PCR ASSAYS FOR COVID-19: A SYSTEMATIC REVIEW Document date: 2020_4_21
ID: g8h6trql_9
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https: //doi.org/10.1101 //doi.org/10. /2020 testing and later found to be positive in a subsequent test are commonly considered cases with an 90 initial false-negative result. Some researchers have suggested that these failures in SARS-CoV-2 91 detection are related to multiple pre-analytical and analytical factors, such as lack of standardisation 92 to collect specime.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https: //doi.org/10.1101 //doi.org/10. /2020 testing and later found to be positive in a subsequent test are commonly considered cases with an 90 initial false-negative result. Some researchers have suggested that these failures in SARS-CoV-2 91 detection are related to multiple pre-analytical and analytical factors, such as lack of standardisation 92 to collect specimens, the time and conservation of samples until to be received in the laboratory, 93 the use of non-adequately validated assays, contamination during the procedure, insufficient viral 94 specimens and load, the incubation period of the disease, and the risk of active recombination and 95 mutation [14, 16] . 96
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