Author: Vanin, A. F.
Title: Dinitrosyl Iron Complexes with Thiol-Containing Ligands Can Suppress Viral Infections as Donors of the Nitrosonium Cation (Hypothesis) Cord-id: h0b0k78n Document date: 2020_10_19
ID: h0b0k78n
Snippet: The appropriateness of verification of the possible antiviral effect of dinitrosyl iron complexes with thiol-containing ligands as donors of nitrosonium cations (NO(+)) is argued. There is reason to hope that treatment of the human respiratory tract and lungs with sprayed solutions of dinitrosyl iron complexes with glutathione or N-acetylcysteine (NAC) ​​as NO(+) donors during COVID-19 infection can initiate S-nitrosylation of cellular proteases and thereby suppress viral infection.
Document: The appropriateness of verification of the possible antiviral effect of dinitrosyl iron complexes with thiol-containing ligands as donors of nitrosonium cations (NO(+)) is argued. There is reason to hope that treatment of the human respiratory tract and lungs with sprayed solutions of dinitrosyl iron complexes with glutathione or N-acetylcysteine (NAC) ​​as NO(+) donors during COVID-19 infection can initiate S-nitrosylation of cellular proteases and thereby suppress viral infection.
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