Author: Hobson, James J; Savage, Alison C; Dwyer, Andrew B; Unsworth, Catherine; Massam, Jonathan; Arshad, Usman; Pertinez, Henry; Box, Helen; Tatham, Lee; Rajoli, Rajith K R; Neary, Megan; Sharp, Joanne; Valentijn, Anthony; David, Christopher; Curley, Paul; Liptrott, Neill J; McDonald, Tom O; Owen, Andrew; Rannard, Steve P
Title: Scalable nanoprecipitation of niclosamide and in vivo demonstration of long-acting delivery after intramuscular injection. Cord-id: j6um8h2o Document date: 2021_4_7
ID: j6um8h2o
Snippet: The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.
Document: The control of COVID-19 across the world requires the formation of a range of interventions including vaccines to elicit an immune response and immunomodulatory or antiviral therapeutics. Here, we demonstrate the nanoparticle formulation of a highly insoluble drug compound, niclosamide, with known anti SARS-CoV-2 activity as a cheap and scalable long-acting injectable antiviral candidate.
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