Author: Shitao Rao; Alexandria Lau; Hon-Cheong So
Title: Exploring diseases/traits and blood proteins causally related to expression of ACE2, the putative receptor of 2019-nCov: A Mendelian Randomization analysis Document date: 2020_3_8
ID: myh73pe6_4
Snippet: In a related work, recently Cai 15 performed an analysis with TCGA datasets and showed that smoking is associated with elevated expression of ACE2 in the lung, which may be associated with greater susceptibility to infection or more severe illness. However, there are several limitations as detailed by the author. For example, the samples studied are derived from patients with lung cancer, which may not be fully reflective of the expression in nor.....
Document: In a related work, recently Cai 15 performed an analysis with TCGA datasets and showed that smoking is associated with elevated expression of ACE2 in the lung, which may be associated with greater susceptibility to infection or more severe illness. However, there are several limitations as detailed by the author. For example, the samples studied are derived from patients with lung cancer, which may not be fully reflective of the expression in normal lung tissues. Another potential limitation is that it is difficult to control for all confounders, as smoking may be related to other unhealthy life habits 16 and multiple comorbid diseases 17, 18 .
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