Author: Leili Zhang; David R. Bell; Binquan Luan; Ruhong Zhou
Title: Exploring the Binding Mechanism between Human Profilin (PFN1) and Polyproline-10 through Binding Mode Screening Document date: 2018_9_16
ID: 40pe21lm_57
Snippet: A correlation between AFM maximal forces and binding constant was reported in a cell adhesion study 54 and an antibody-antigen unbinding study 54 . Here we investigate how maximal forces from SMD (with a much faster rupture rate) correlate with the PMFs. With two rupture rates, R 2 is calculated to be 0.53 for 1 nm/ns SMD, and 0.21 for 0.1 nm/ns SMD, respectively. Dependent on the separation pathway selected on a free energy landscape, overall ma.....
Document: A correlation between AFM maximal forces and binding constant was reported in a cell adhesion study 54 and an antibody-antigen unbinding study 54 . Here we investigate how maximal forces from SMD (with a much faster rupture rate) correlate with the PMFs. With two rupture rates, R 2 is calculated to be 0.53 for 1 nm/ns SMD, and 0.21 for 0.1 nm/ns SMD, respectively. Dependent on the separation pathway selected on a free energy landscape, overall maximal forces are unsatisfactory for predicting the trend of binding free energies. The correlation may simply come All rights reserved. No reuse allowed without permission.
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