Selected article for: "amino acid and generation sequencing"
Author: Do, Hai-Quynh; Nguyen, Van-Giap; Chung, Chul-Un; Jeon, Yong-Shin; Shin, Sook; Jang, Kuem-Chan; Pham, Le Bich Hang; Kong, Aeri; Kim, Cheong-Ung; Park, Yong-Ho; Park, Bong-Kyun; Chung, Hee-Chun
Title: Genomic Characterization of a Novel Alphacoronavirus Isolated from Bats, Korea, 2020
  • Cord-id: ie27ejsc
  • Document date: 2021_10_11
    • ID: ie27ejsc
    Snippet: Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of coronaviruses in bats are essential in order to prevent the risk of future diseases. In this study, the genome of HCQD-2020, a novel alphacoronavirus detected in a bat (Eptesicus serotinus), was assembled and described using next-generation sequ
    Document: Coronavirus, an important zoonotic disease, raises concerns of future pandemics. The bat is considered a source of noticeable viruses resulting in human and livestock infections, especially the coronavirus. Therefore, surveillance and genetic analysis of coronaviruses in bats are essential in order to prevent the risk of future diseases. In this study, the genome of HCQD-2020, a novel alphacoronavirus detected in a bat (Eptesicus serotinus), was assembled and described using next-generation sequencing and bioinformatics analysis. The comparison of the whole-genome sequence and the conserved amino acid sequence of replicated proteins revealed that the new strain was distantly related with other known species in the Alphacoronavirus genus. Phylogenetic construction indicated that this strain formed a separated branch with other species, suggesting a new species of Alphacoronavirus. Additionally, in silico prediction also revealed the risk of cross-species infection of this strain, especially in the order Artiodactyla. In summary, this study provided the genetic characteristics of a possible new species belonging to Alphacoronavirus.

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