Author: Vavougios, George D.; Ntoskas, Konstantinos T.; Doskas, Triantafyllos K.
Title: Impairment in selenocysteine synthesis as a candidate mechanism of inducible coagulopathy in COVID-19 patients Cord-id: 8ckxkn6n Document date: 2020_12_26
ID: 8ckxkn6n
Snippet: Coagulopathy has recently been recognized as a recurring complication of COVID-19, most typically associated with critical illness. There are epidemiological, mechanistic and transcriptomic evidence that link Selenium with SARS-CoV-2’s intracellular latency. Taking into consideration the vital role of selenoproteins in maintaining an adequate immune response, endothelial homeostasis and a non-prothrombotic platelet activation status, we propose that impairment in selenocysteine synthesis, via
Document: Coagulopathy has recently been recognized as a recurring complication of COVID-19, most typically associated with critical illness. There are epidemiological, mechanistic and transcriptomic evidence that link Selenium with SARS-CoV-2’s intracellular latency. Taking into consideration the vital role of selenoproteins in maintaining an adequate immune response, endothelial homeostasis and a non-prothrombotic platelet activation status, we propose that impairment in selenocysteine synthesis, via perturbations in the aforementioned physiological functions, potentially constitutes a mechanism of coagulopathy in COVID 19 patients other than those developed in critical illness.
Search related documents:
Co phrase search for related documents- acute coronary syndrome and adaptive immunity: 1
- acute coronary syndrome and adaptive immunity innate: 1
- acute coronary syndrome and lung tissue: 1, 2
- adaptive immunity and lung macrophage: 1
- adaptive immunity and lung parenchyma: 1
- adaptive immunity and lung tissue: 1, 2, 3, 4, 5, 6, 7
- adaptive immunity innate and lung macrophage: 1
- adaptive immunity innate and lung tissue: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date