Author: Karen N. Barnard; Brian R. Wasik; Justin R. LaClair; Wendy S. Weichert; Brynn K. Lawrence; Colin R. Parrish
Title: Expression of 9-O- and 7,9-O-acetyl modified sialic acid in cells and their effects on influenza viruses Document date: 2019_5_25
ID: edslp6l5_2
Snippet: At least one sialate O-acetylesterase (SIAE) enzyme regulates the display of 7, O-and 9-O-Ac in many cells and tissues (Fig. 1B) . The SIAE gene encodes two 79 isoforms that vary in the presence of a proposed C-terminal localization tag in the 80 lysosomal (Lse) form that is absent from the cytosolic form (Cse) (12). However, the 81 processes that regulate the expression and activity of these two isoforms remain poorly 82 defined. Lse has been fo.....
Document: At least one sialate O-acetylesterase (SIAE) enzyme regulates the display of 7, O-and 9-O-Ac in many cells and tissues (Fig. 1B) . The SIAE gene encodes two 79 isoforms that vary in the presence of a proposed C-terminal localization tag in the 80 lysosomal (Lse) form that is absent from the cytosolic form (Cse) (12). However, the 81 processes that regulate the expression and activity of these two isoforms remain poorly 82 defined. Lse has been found to localize to the Golgi and/or ER and on the surface of 83 cells when over-expressed, with the majority being secreted into the supernatant (12). 84
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