Extensive genetic diversity of bat-borne polyomaviruses reveals inter-family host-switching events

Zhizhou Tan; Gabriel Gonzalez; Jinliang Sheng; Jianmin Wu; Fuqiang Zhang; Lin Xu; Peisheng Zhang; Aiwei Zhu; Yonggang Qu; Changchun Tu; Michael J. Carr; Biao He

The divergence correlation between the hosts and PyVs in the Alpha-and Betapolyomavirus 638 genera was assessed by applying Mantel's correlation tests to the pairwise evolutionary distance 639 matrices for hosts and viral samples in both genera with 10 4 repetitions. Additionally, the 640 matrices were also analysed against the geographical distance between sampling points, and 641 partial correlations between host and polyomavirus distance matrices were estimated controlling 642 for the correlation with the geographical distance. The correlation analysis was performed 643 considering three sets of data per genus: 1) considering only samples identified in China, 2) . CC-BY 4.0 International license is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. It . https://doi.org/10.1101/627158 doi: bioRxiv preprint considering samples identified in China and samples identified in Africa [26] , and 3) removing 645 samples from 2) such as the correlation index increased. Removed samples in 3) were chosen by 646 estimating the correlation coefficient without each sample and then removing samples whose 647 absence maximized the correlation between hosts and PyVs.