Author: Kevin W. Graepel; Maria L. Agostini; Xiaotao Lu; Nicole R. Sexton; Mark R. Denison
Title: Fitness barriers limit reversion of a proofreading-deficient coronavirus Document date: 2019_4_26
ID: 8pr10j88_26
Snippet: Ct thresholds (DCtcompetitor = Ctcompetitor -Ctreference) and converted to reflect the fold-change in 373 ratio (Dratio = 2 -DCt competitor ). The log10Dratio was plotted against passage number, and the change 374 in log10Dratio (i.e. slope of linear regression) is the relative fitness. Note that regressions were fit 375 only through P1-P4, as slight deviations in 1:1 ratio in the input (P0) can skew the slope. The copyright holder for this prepr.....
Document: Ct thresholds (DCtcompetitor = Ctcompetitor -Ctreference) and converted to reflect the fold-change in 373 ratio (Dratio = 2 -DCt competitor ). The log10Dratio was plotted against passage number, and the change 374 in log10Dratio (i.e. slope of linear regression) is the relative fitness. Note that regressions were fit 375 only through P1-P4, as slight deviations in 1:1 ratio in the input (P0) can skew the slope. The copyright holder for this preprint (which was not peer-reviewed) is the author/funder. . https://doi.org/10.1101/618249 doi: bioRxiv preprint
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