Selected article for: "cell type and program gene"
Author: Atianand, Maninjay K.; Fitzgerald, Katherine A.
Title: Long non-coding RNAs and control of gene expression in the immune system
  • Cord-id: jcfe36u6
  • Document date: 2014_11_1
    • ID: jcfe36u6
    Snippet: All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNA), have emerged as important regulators of gene expression in diverse biological contexts. Long non-coding RNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability or trans
    Document: All cells of the immune system rely on a highly integrated and dynamic gene expression program that is controlled by both transcriptional and post-transcriptional mechanisms. Recently, non-coding RNAs, including long non-coding RNAs (lncRNA), have emerged as important regulators of gene expression in diverse biological contexts. Long non-coding RNAs control gene expression in the nucleus by modulating transcription or via post-transcriptional mechanisms targeting the splicing, stability or translation of mRNAs. Our knowledge of lncRNA biogenesis, their cell-type specific expressions, and their versatile molecular functions are rapidly progressing in all areas of biology. Here we discuss these exciting new regulators and highlight an emerging paradigm of lncRNA-mediated control of gene expression in the immune system.

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