A novel antiviral formulation inhibits a range of enveloped viruses.

Nicola F Fletcher; Luke W Meredith; Emma L Tidswell; Steven R Bryden; Daniel Gonçalves-Carneiro; Yasmin Chaudhry; Claire Shannon-Lowe; Michael A Folan; Daniella A Lefteri; Marieke Pingen; Dalan Bailey; Clive S McKimmie; Alan W Baird

The copyright holder for this preprint (which was not peer-reviewed) is . https://doi.org/10.1101/2020.03.29.009464 doi: bioRxiv preprint 300nm in diameter) and the relatively high titres that can be achieved following growth in cell culture. Negatively stained virions exhibited typical poxvirus morphology ( Figure 5A) , with an ovoid structure surrounded by an external envelope. Treatment of orf virions with 1% ViroSAL, which neutralized approximately 50% infection in infection assays ( Figure 3B ), appeared to disrupt the external viral envelope, which remained associated with the virions ( Figure 5B ). Treatment with 3% ViroSAL, which completely neutralized in vitro infectivity ( Figure 3B ) disrupted virion morphology and the lattice-like structure present on intact virions ( Figure 5C ).