Author: Ingrid Arevalo-Rodriguez; Diana Buitrago-Garcia; Daniel Simancas-Racines; Paula Zambrano-Achig; Rosa del Campo; Agustin Ciapponi; Omar Sued; Laura Martinez-Garcia; Anne Rutjes; Nicola Low; Jose A Perez-Molina; Javier Zamora
Title: FALSE-NEGATIVE RESULTS OF INITIAL RT-PCR ASSAYS FOR COVID-19: A SYSTEMATIC REVIEW Document date: 2020_4_21
ID: g8h6trql_30
Snippet: We rated the certainty of the evidence about false-negative cases following the GRADE approach 180 for tests and strategies [22, 23] . We assessed the quality of evidence as high, moderate, low or very 181 low, depending on several factors including risk of bias, imprecision, inconsistency, indirectness, and 182 publication bias. We illustrate the consequences of the numerical findings in a population of 100 183 tested, according to three differe.....
Document: We rated the certainty of the evidence about false-negative cases following the GRADE approach 180 for tests and strategies [22, 23] . We assessed the quality of evidence as high, moderate, low or very 181 low, depending on several factors including risk of bias, imprecision, inconsistency, indirectness, and 182 publication bias. We illustrate the consequences of the numerical findings in a population of 100 183 tested, according to three different prevalence estimates of the disease provided by the 184 stakeholders involved in this review. 185 . CC-BY-NC-ND 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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