Author: Ingrid Arevalo-Rodriguez; Diana Buitrago-Garcia; Daniel Simancas-Racines; Paula Zambrano-Achig; Rosa del Campo; Agustin Ciapponi; Omar Sued; Laura Martinez-Garcia; Anne Rutjes; Nicola Low; Jose A Perez-Molina; Javier Zamora
Title: FALSE-NEGATIVE RESULTS OF INITIAL RT-PCR ASSAYS FOR COVID-19: A SYSTEMATIC REVIEW Document date: 2020_4_21
ID: g8h6trql_41
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https: //doi.org/10.1101 //doi.org/10. /2020 studies collected upper or lower respiratory specimens; b) all studies included patients with clinical 243 findings suggestive of COVID 19 disease; c) subgroup information by the time of evolution of 244 symptom was only provided by one study; and d) key information about the characteristics of the 245 index test, such as pos.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https: //doi.org/10.1101 //doi.org/10. /2020 studies collected upper or lower respiratory specimens; b) all studies included patients with clinical 243 findings suggestive of COVID 19 disease; c) subgroup information by the time of evolution of 244 symptom was only provided by one study; and d) key information about the characteristics of the 245 index test, such as positivity criteria, were not reported. The high variability of pooled estimation 246 was not reduced with the separate estimation of false-negative proportion by type of study 247 (accuracy versus case series). 248 249
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