Author: Kelton, John Greenhow; Arnold, Donald Mitchell; Nazy, Ishac
Title: Lessons from vaccine-induced immune thrombotic thrombocytopenia Cord-id: j7v03gdb Document date: 2021_10_18
ID: j7v03gdb
Snippet: Adenoviral vector vaccines are effective against SARS-CoV-2 but have been associated with a rare side effect termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we discuss our understanding of how vaccine-induced antibodies to platelet factor 4 (PF4) form immune complexes that activate platelets and trigger the thrombotic events seen in VITT.
Document: Adenoviral vector vaccines are effective against SARS-CoV-2 but have been associated with a rare side effect termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Here, we discuss our understanding of how vaccine-induced antibodies to platelet factor 4 (PF4) form immune complexes that activate platelets and trigger the thrombotic events seen in VITT.
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