Author: Zavyalova, Elena; Ambartsumyan, Oganes; Zhdanov, Gleb; Gribanyov, Dmitry; Gushchin, Vladimir; Tkachuk, Artem; Rudakova, Elena; Nikiforova, Maria; Kuznetsova, Nadezhda; Popova, Liubov; Verdiev, Bakhtiyar; Alatyrev, Artem; Burtseva, Elena; Ignatieva, Anna; Iliukhina, Anna; Dolzhikova, Inna; Arutyunyan, Alexander; Gambaryan, Alexandra; Kukushkin, Vladimir
Title: SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2 Cord-id: e0djh8x8 Document date: 2021_5_25
ID: e0djh8x8
Snippet: During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expens
Document: During the COVID-19 pandemic, the development of sensitive and rapid techniques for detection of viruses have become vital. Surface-enhanced Raman scattering (SERS) is an appropriate tool for new techniques due to its high sensitivity. SERS materials modified with short-structured oligonucleotides (DNA aptamers) provide specificity for SERS biosensors. Existing SERS-based aptasensors for rapid virus detection are either inapplicable for quantitative determination or have sophisticated and expensive construction and implementation. In this paper, we provide a SERS-aptasensor based on colloidal solutions which combines rapidity and specificity in quantitative determination of SARS-CoV-2 virus, discriminating it from the other respiratory viruses.
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